Friday, April 5th *Speakers and titles are subject to change
Session   Speaker Company Time
Registration and Breakfast     7:30AM-8:30AM
Conference Opening Matt Hayward   Pfizer 8:30AM-8:40AM

Opening Plenary Lecture

Chemistry Towards Novel Mechanism-of-Action Compounds in Therapeutics Discovery

Stuart Schreiber Broad Institute and Harvard 8:40AM-9:25AM

SESSION I: Tumor Metabolism and Immunometabolism

Session Chair: Susan Ashwell, Ra Pharmaceuticals

  Topic Speaker Company Time
Session Introduction     9:25AM-9:30AM
Novel STING Agonists for Immuno-oncology Jared Cumming  Merck 9:30AM-10:00AM
Discovery of Clinical Candidate IDH305, a Mutant IDH1 Inhibitor Thomas Caferro   Novartis 10:00AM-10:30AM
Break     10:30AM-10:50AM
  Peter Cornelius SynDevRx 10:50AM-11:20AM

SESSION II: Recent Success Stories

Session Chair: Louis Chupak, Bristol-Myers Squibb

  Topic Speaker Company Time
Session Introduction     11:20AM-11:25AM
Inhibition of Autoimmune Pathways with Dual Inhibition of JAK1 and TYK2: Discovery of PF-06700841  Andrew Fensome Pfizer 11:25AM-11:55AM
Inhibition of TYK2 via the Pseudokinase: The Discovery of BMS-986165 Ryan Moslin  BMS 11:55AM-12:25PM
Lunch     12:25PM-1:40PM
Discovery of AMG 986, a Potent, Selective and Orally Bioavailable APJ Agonist for theTreatment of Heart Disease Paul Dransfield  Amgen  1:40PM-2:10PM
  TBA  Ra Pharmaceuticals 2:10PM-2:40PM

Session III: Strategies for Drugging Difficult Targets

Session Chair: Benoit Moreau, Syros Pharmaceuticals

Session Introduction     2:40PM-2:45PM
"Shining The Light on Small Molecule Inhibitors of MCT4” Aarti Kawatkar AstraZeneca 2:45PM-3:15PM
Break       3:15PM-3:35PM
Scalable Combinatorial Screening of Microbes  Paul Blainey Broad Institute and MIT 3:35PM-4:05PM
Physics-Based Drug Discovery for Tackling Challenge Targets  Deqiang Niu Silicon Therapeutics 4:05PM-4:35PM
Targeting Intracellular Protein-Protein Interactions with Macrocyclic Peptides  Dehua Pei The Ohio State University 4:35PM-5:05PM
Closing Remarks     5:05PM-5:10PM

Poster Session and Evening Reception



Session I:  Tumor Metabolism and Immunometabolism

Session II: Recent Success Stories

Session III: Strategies for Drugging Difficult Targets


Click here to register for the APC 2019 conference online.

APC 2019 will take place April 5, 2019 at:

Broad Institute, Cambridge, MA


The Boston Society

The Boston Society (R) is an internationally-recognized NON-PROFIT organization dedicated to bringing the best scientific ideas to industrial practice through focused, timely workshops and conferences. 501(c)3


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