Friday, April 5th *Speakers and titles are subject to change
Session   Speaker Company Time
Registration and Breakfast     7:30AM-8:30AM
Conference Opening Matt Hayward   Pfizer 8:30AM-8:40AM

Opening Plenary Lecture

Chemistry Towards Novel Mechanism-of-Action Compounds in Therapeutics Discovery

Stuart Schreiber Broad Institute and Harvard 8:40AM-9:25AM

SESSION I: Tumor Metabolism and Immunometabolism

Session Chair: Susan Ashwell, Ra Pharmaceuticals

  Topic Speaker Company Time
Session Introduction     9:25AM-9:30AM
Novel STING Agonists for Immuno-oncology Wes Trotter Merck 9:30AM-10:00AM
Discovery of Clinical Candidate IDH305, a Mutant IDH1 Inhibitor Thomas Caferro   Novartis 10:00AM-10:30AM
Break     10:30AM-10:45AM
SDX-7320: a Novel Polymer-Conjugated MetAP2 Inhibitor for Cancers Stimulated by Metabolic Hormones Peter Cornelius SynDevRx 10:45AM-11:15AM

SESSION II: Recent Success Stories

Session Chair: Louis Chupak, Bristol-Myers Squibb

  Topic Speaker Company Time
Session Introduction     11:15AM-11:20AM
Inhibition of Autoimmune Pathways with Dual Inhibition of JAK1 and TYK2: Discovery of PF-06700841  Andrew Fensome Pfizer 11:20AM-11:50AM
Inhibition of TYK2 via the Pseudokinase: The Discovery of BMS-986165 Ryan Moslin  BMS 11:50AM-12:20PM
Lunch     12:20PM-1:20PM
Discovery of AMG 986, a Potent, Selective and Orally Bioavailable APJ Agonist for theTreatment of Heart Disease Paul Dransfield  Amgen  1:20PM-1:50PM
Discovery and Development of Macrocyclic Peptides for the Treatment of Complement-Mediated Disorders Susan Ashwell  Ra Pharmaceuticals 1:50PM-2:20PM

Session III: Strategies for Drugging Difficult Targets

Session Chair: Benoit Moreau, Syros Pharmaceuticals

Session Introduction     2:20PM-2:25PM
Shining The Light on Small Molecule Inhibitors of MCT4 Aarti Kawatkar AstraZeneca 2:25PM-2:55PM
Targeting Intracellular Protein-Protein Interactions with Macrocyclic Peptides Dehua Pei The Ohio State University 2:55PM-3:25PM
Break     3:25PM-3:40PM
Physics-Based Drug Discovery for Tackling Challenge Targets  Woody Sherman Silicon Therapeutics 3:40PM-4:10PM
Scalable Combinatorial Screening of Microbes  Paul Blainey Broad Institute and MIT 4:10PM-4:40PM
Synthetic Macrocycles for the Inhibition of Challenging PPI Targets Adrian Whitty Boston University 4:40PM-5:10PM
Closing Remarks     5:10PM-5:15PM

Poster Session and Evening Reception



Session I:  Tumor Metabolism and Immunometabolism

Session II: Recent Success Stories

Session III: Strategies for Drugging Difficult Targets


Click here to register for the APC 2019 conference online.

APC 2019 will take place April 5, 2019 at:

Broad Institute, Cambridge, MA


The Boston Society

The Boston Society (R) is an internationally-recognized NON-PROFIT organization dedicated to bringing the best scientific ideas to industrial practice through focused, timely workshops and conferences. 501(c)3


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