Thursday April 4, 2024

Updated 2/26/2024 *Speakers and titles are subject to change
Session   Speaker Company Time
Registration and Coffee     8:00AM-9:00AM
Conference Opening Pedro Garcia Barrantes Vertex 9:00AM-9:05AM
Speaker Introduction



MTA-cooperative PRMT5 Inhibitors For the Treatment of MTAP-deleted Cancers

Kevin Cottrell Tango Therapeutics 9:10AM-9:40AM
Speaker Introduction  Eamonn Comer  Kymera Therapeutics 9:40AM-9:45AM
Discovery of Potent, Orally Bioavailable IRAK4 Degraders for the Treatment of Oncology and Immuno-Inflammatory Diseases Matt Weiss Kymera Therapeutics 9:45AM-10:15AM
Speaker Introduction  Kenneth Boy  BMS 10:15AM-10:20AM
Sustainability-Driven Science: How Process Chemistry at Sanofi Integrates Eco-Design with Process Development Eileen Hoang Sanofi 10:20AM-10:50AM
AM Break     10:50AM-11:10AM
Speaker Introduction  Andy Tsai  Treeline Bio 11:10AM-11:15AM
Discovery and Characterization of a First-in-Class Selective IKZF2 Glue Degrader for Immuno-Oncology Applications Michael Visser Novartis


Plenary Speaker Introduction Catherine Lebrun Ananke Therapeutics 11:45AM-11:50AM

Plenary Lecture

Next-Generation Covalent Drug Discovery – Targeting Residues Beyond Cysteine

Lyn Jones Dana-Farber Cancer Institute 11:50AM-12:35PM
Lunch     12:35PM-1:50PM
Speaker Introduction  David Ebner  Pfizer 1:50PM-1:55PM
Vendor Talk - Exploiting High-Energy Hydration Sites for the Discovery of Potent Peptide Aldehyde Inhibitors of the SARS-CoV-2 Main Protease with Cellular Antiviral Activity Abba Leffler 1:55PM-2:20PM
Small Molecule GLP-1 Receptor Agonists Suitable for Once-daily Oral Administration David Griffith Pfizer 2:20PM-2:50PM
Speaker Introduction  Benoit Moreau  Remix Therapeutics 2:50PM-2:55PM
Rational Discovery and Design of Molecular Glue Degraders Bernhard Fasching Monte Rosa Therapeutics 2:55PM-3:25PM
PM Break     3:25PM-3:40PM
Speaker Introduction  Andy Tsai  Treeline Bio 3:40PM-3:45PM
Identification of a Novel Linker Enabling Bioconjugation of a Cyclic Dinucleotide for the STING Antibody Drug Conjugate TAK-500 Hong Myung Lee Takeda 3:45PM-4:15PM
Plenary Speaker Introduction  Rebecca Casaubon  Exscientia 4:15PM-4:20PM

Plenary Lecture

Chemical Synthesis of Complex Molecules for Translational Science

John A. Porco, Jr. Boston University 4:20PM-5:05PM
Closing Remarks David Ebner Pfizer 5:05PM - 5:10PM
Reception     5:10PM-6:10PM


Session I:  TBA

Session II: TBA

Session III: TBA


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APC 2024 will take place April 4, 2024 at:

Pfizer, Cambridge, MA


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