*Speakers and titles are subject to change. Updated 03/18/22

*TIME SLOTS LISTED BELOW ARE EDT!!! 

Thursday, June 16, 2022

Talk Title 

Speaker

Company

Time

EDT

Registration   

   

8:00 - 9:00

Conference Opening

 Ruchia Duggal  Merck

9:00 - 9:10

SESSION I: Advances in ADME of New Modalities

Chairs: Mitesh Patel, Novartis & Ruchia Duggal, Merck

Session I Opening Remarks 

9:10 - 8:15

Of Mice and Man: Path to Clinical CRISPR/Cas9 Genome Editing Therapeutic Development

Yuanxin Xu 

Intellia Therapeutics

9:15 - 9:40

The Knowns and Unknowns of ADME/PK of Targeted Protein Degraders  Haojing Rong  Kymera Therapeutics

9:40 - 10:05

Showcase:      
Plenary Lecture: How Understanding ADME Properties of Multispecific Biologics Can Increase Speed to the Clinic

 Brooke Rock

Amgen

10:05 - 10:45

Break    

10:45 - 11:05

Showcase:       

SESSION II: Novel In Silico Tools for ADME in Drug Discovery

Chairs: Maria Fitzgerald, Epizyme & Vinayak Hosagrahara, Nimbus Therapeutics

Session II Opening Remarks 

11:05 - 11:10

Populations of Models for Virtual Patient/Cohort Construction in ADME/PK  James Kozloski IBM

11:10 - 11:35

Prediction Accuracy of Volume of Distribution Using In Vitro, In Vivo, PBPK, and QSAR Methods Li Di  Pfizer

11:35 - 12:00

Mechanistic Modelling of Caco-2 Experiments to Estimate Intrinsic Permeability  Mailys Mendes Certara UK

12:00- 12:25

Lunch    

12:25 - 1:25

Long-term HEPATOPAC® Cultures: Model Validation for ADME-Tox Applications                          Dipen Vyas 

1:25- 1:50

Showcase:       

SESSION III: Contributions of Vascular and Lymphatic Compartments to Drug Absorption

Chairs: Dallas Bednarczyk, Novartis & Jun Zhang, BMS

 

Session III Opening Remarks 

1:50 - 1:55

Plenary Lecture: Vascular and Lymphatic Barrier Function in the Brain and Subcutaneous Compartments

 Roger Kamm

MIT

1:55 - 2:35

Tools Toward Predicting Oral Lymphatic Adsorption  Ryan Pelis Novartis

2:35 - 3:00

Break    

3:00 - 3:20

Showcase:       

SESSION IV: ADME of COVID Therapeutics and Beyond

Chairs: Steven Louie, Novartis & Chris Rowbottom, Moderna

Session IV Opening Remarks

3:20 - 3:25

Assessment of Amino Lipid Biodistribution, Metabolism, and Elimination in Rats after LNP IV Administration to Understand In Vivo Fate and Potential for DDI

Doug Burdette  Moderna

3:25- 3:50

Panel Discussion: Expedited Drug Discovery Post-COVID

Brooke Rock, Amgen, Li Di, Pfizer, Doug Burdette, Moderna, Charlie Knutson, Novartis  

3:50 - 4:15

Closing Remarks

 Chris Rowbottom Moderna 

4:15 - 4:20

Reception

   

4:20- 5:20

Workshops

Session I: Advances in ADME of New Modalities

Session II: Novel in silico Tools for ADME in Drug Discovery

Session III: Drug Delivery to Unusual Targets

Session IV: ADME of COVID Therapeutics and Beyond

 

Registration

Click here to register for the NE-ADME conference online.

NE-ADME 2022 will take place June 16, 2022

Novartis, Cambridge, MA

 

The Boston Society

The Boston Society (R) is an internationally-recognized NON-PROFIT organization dedicated to bringing the best scientific ideas to industrial practice through focused, timely workshops and conferences. 501(c)3

Updates

Sign Up Today!

Privacy Policy