Thursday, June 13 2024

Talk Title 







7:30 - 8:30

Conference Opening and Plenary Lecture Introduction

 Mitesh Patel Novartis

8:30 - 8:40

Plenary Lecture: ECCS Class 3A: Interaction of Gabapentin and Its Analogues with Transporters - A Love-Hate Relationship Ayman El-Kattan IFM Therapeutics

8:40 - 9:20

SESSION I: Complex Models to Support Drug Development

Chairs: Mitesh Patel, Novartis & Ruchia Duggal, Merck

Session I Opening Remarks 

9:42 - 9:25

Utilizing Ex Vivo Liver Slice Models for Preclinical Evaluation of LNP-Based mRNA Delivery

Hema Muralidharan


9:25 - 9:55

Liver MPS Model Comparison for Clearance IVIVC

Birk Poller

Novartis, Basel

9:55 - 10:25

Overcoming Limitations of Caco-2 Cells for ADME Using Adult Human Crypt-Derived Planar Intestinal Epithelium Cultures Ben Scruggs  Altis Biosystems  10:25 - 10:55

10:55 - 11:15

Plenary Speaker Introduction Vinayak Hosagrahara  Nimbus Therapeutics  11:15 - 11:20
Plenary Lecture: ADMET In The Age of AI Daniel Price Nimbus Therapeutics

11:20 - 12:00

Fatty Liver Disease Modeling In a Micropatterned Primary Hepatocyte Co-culture (HEPATOPAC): Applications In Drug Development & Screening Karissa Cottier

12:00 - 12:25


12:25 - 1:35

Cryo-Fluorescence Tomography: Transformative 3D Imaging to Monitor Drug PK/PD Matt Silva  

1:35 - 1:45

SESSION II: PK/PD for New Modalities

Chairs: Steven Louie, Moderna & Dallas Bednarczyk, Novartis

Session II Opening Remarks 

1:45 - 1:50

Use of PK/PD Modeling to Understand the Potential and Pitfalls of New Modalities- Picking the Winners from the Losers  Alison Betts Takeda

1:50 - 2:20

Dynamical Modeling of Protein Degradation to Improve Compound Selection in Drug Discovery TK Phung Novartis

2:20 - 2:50

Pharmacokinetics and Distribution of Lipid Nanoparticles Christopher Rowbottom Moderna

2:50- 3:20


3:20 - 3:40

SESSION III: Advanced Tools to Support Drug Discovery & Development

Chairs: Joseph Tillotson, Pfizer & Seema Chauhan Kumar, Pioneering Medicines 

Session III Opening Remarks 

3:40 - 3:45

Measurement of Target Exposure and Binding with Positron Emission Tomography (PET) Imaging in Drug Research and Development Laigao Chen Pfizer

3:45 - 4:15

Early Drug-Induced Liver Injury Risk Screening: “Free,” as Good as it Gets Jonathan Jackson Pfizer

4:15 - 4:45

Closing Remarks

 Seema Chauhan Kumar  Pioneering Medicines

4:45- 4:50



4:50- 5:50


Session I: Complex Models to Support Drug Development

Session II: PK/PD of New Modalities

Session III: Advanced Tools to Support Drug Discovery and Development



Click here to register for the NE-ADME conference online.

NE-ADME 2024 will take place June 13, 2024

Merck, Boston, MA


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