*Speakers and titles are subject to change. Updated 6/10/2021

*TIME SLOTS LISTED BELOW ARE EDT!!!

Tuesday, June 22, 2021

Session

 

Speaker

Company

Time

EDT

Conference Opening & Plenary Speaker Introduction   

 Maria Fitzgerald  Sanofi

10:00 - 10:05

Plenary Lecture

Liquid Biopsy in ADME: Where are We Now and Where are We Going?

 David Rodrigues

Pfizer

10:05 - 10:45

Q&A    

10:45 - 10:55

SESSION I: Impact of Free Fraction in ADME

Session Intro:

Ruchia Duggal, Merck & Chris Rowbottom, Moderna

 

10:55 - 11:00

Improved IVIVE for Hepatic Clearance Prediction: The Impact of Albumin on Hepatic Uptake

Na Li 

C4 Therapeutics

11:00 - 11:30

Q&A    

11:30 - 11:40

Unbound Volume of Distribution as a Foundational Parameter in Drug Design

Randy Miller &

Iain Martin

Merck

Relay Therapeutics

11:40 - 12:25

Q&A    

12:25 - 12:35

Lunch Break & Sponsor Showcase    

12:35 - 1:25

Speaker Intro: Chris Rowbottom, Moderna    

1:25:1:30

High Throughput Physical Chemistry Assays: Advances and Application  Mark Wenlock

1:30 - 1:55

Q&A    

1:55 - 2:00

SESSION II: In Silico ADME

 

Session Introduction

John Janiszewski, NIH & Wilson Shou, BMS 

 

2:00 - 2:05

NCATS ADME Datasets and In Silico Models Derived from these Datasets 

Xin Xu

NIH

2:05 - 2:35

Q&A    

2:35 - 2:45

Speaker Intro:     2:45 - 2:50
Mechanistic Insights Into the Inhibitor Preincubation Effect

Peter Tatrai 

Solvo Biotechnology Logo

2:50 - 3:15
Q&A     3:15- 3:20
HT-ADME: From Data to Knowledge. Generate Data to Feed AI Model Generation and Reach Optimal Compound Design  Ismael Zamora  

3:20 - 3:40

Q&A    

3:40 - 3:45

Plenary Speaker Intro John Janiszewski, NIH   

3:45 - 3:50

Plenary Lecture

Influencing Design with in silico ADME Models

Marcel Hop

Genentech

 3:50 - 4:30

Q&A

    4:30 - 4:40

Wednesday, June 23, 2021

SESSION III: ADME for New Modalities

 

Session Introduction

 

 

10:00 - 10:05

AAV Gene Therapies - new opportunities for ADME Scientists

Mark Milton

Novartis

10:05 - 10:35

Q&A    

10:35 - 10:45

Quantitative and Qualitative Aspects of PROTAC Metabolism: Do they differ from small molecule?

Beth Williamson

 AstraZeneca, UK

10:45 -11:15

Q&A

 

 

11:15 - 11:25

999Elite™ Cryopreserved Human Hepatocytes

Albert Li

11:25 - 11:50

Q&A    

11:50- 11:55

Lunch Break & Sponsor Showcase    

11:55 - 1:00

SESSION IV: Drug Accumulation/Transporters

Session Introduction

Mitesh Patel  Novartis 

1:00 - 1:05

The Impact of Ion Trapping on the Cellular Accumulation of Highly Permeable Low Molecular Weight Acidic Drugs

Dallas Bednarczyk

Novartis

1:05 - 1:35

Q&A    

1:35 - 1:45

Validation of PXB Chimeric Mice with Humanized Liver to Predict Human Liver-to-Plasma Kpuu of OATP1B1 Substrates Bo Feng Vertex

1:45 - 2:15

Q&A    

2:15 - 2:25

Drug Interaction Mediated by Transporter Induction: Current Status and Perspective Xinning Yang FDA 2:25 - 2:55
Q&A     2:55 - 3:05
 Importance of Polarized Models for the Evaluation of Hepatic Transporter Based Drug Interactions Kenneth R. Brouwer 

3:05 - 3:15

Q&A    

3:15 - 3:20

SESSION V: COVID and ADME

Session Introduction

Maria Fitzgerald, Sanofi & Steven Louie, Novartis  

3:20 - 3:25

Plenary Lecture

High Throughput Screening and Real World Biomarkers to Predict Drug-Drug and Drug-Nutrient Interactions: Implications to polypharmacy associated with COVID

Kathy Giacomini  UCSF

3:25 - 4:05 

Plenary Lecture

ADME data on Remdesivir/Treatment Efficacy

Yurong Lai Gilead

4:05 - 4:45

Panel Discussion Plenary Speakers

   

4:45 - 5:00 

Closing Remarks      5:00 - 5:05

Workshops

Session I: TBA

Session II: TBA

Session III: TBA

Session IV: TBA

 

Registration

Click here to register for the NE-ADME conference online.

NE-ADME 2022 will take place June 16, 2022

Merck, Boston

 

The Boston Society

The Boston Society (R) is an internationally-recognized NON-PROFIT organization dedicated to bringing the best scientific ideas to industrial practice through focused, timely workshops and conferences. 501(c)3

Updates

Sign Up Today!

Privacy Policy