*Speakers and titles are subject to change. Updated 3/23/2021

Tuesday, June 22, 2021

Session

 

Speaker

Company

Time

Conference Opening & Plenary Speaker Introduction   

 Maria Fitzgerald  Sanofi

10:00 - 10:05

Plenary Lecture

Liquid Biopsy in ADME: Where are We Now and Where are We Going?

 David Rodrigues

Pfizer

10:05 - 10:45

Q&A    

10:45 - 10:55

SESSION I: Impact of Free Fraction in ADME

Albumin-Mediated Hepatocyte Uptake IVIVE & Protein Binding Work Collaboration with Biogen

Na Li 

C4 Therapeutics

10:55 - 11:25

Q&A    

11:25 - 11:35

Unbound Volume of Distribution as a Foundational Parameter in Drug Design

Randy Miller &

Iain Martin

Merck

Relay Therapeutics

11:35 - 12:20

Q&A    

12:20 - 12:30

Lunch Break    

12:30 - 1:30

Vendor Presentation: Talk title TBA  Mark Wenlock

1:30 - 1:55

Q&A    

1:55 - 2:00

SESSION II: In Silico ADME

 

Session Introduction

 

 

2:00 - 2:05

NCATS ADME Datasets and In Silico Models Derived from these Datasets 

Xin Xu

NIH

2:05 - 2:35

Q&A    

2:35 - 2:45

Vendor Presentation

 

Solvo Biotechnology Logo

2:45 - 3:10
Q&A     3:10- 3:15
TBD    

3:15 - 3:35

Q&A    

3:35 - 3:40

Plenary Speaker Intro    

3:40 - 3:45

Plenary Lecture

Influencing Design with in silico ADME Models

Marcel Hop

Genentech

 3:45 - 4:25

Q&A

    4:25 - 4:30

Wednesday, June 23, 2021

SESSION III: ADME for New Modalities

 

Session Introduction

 

 

10:00 - 10:05

AAV Gene Therapies - new opportunities for ADME Scientists

Mark Milton

Novartis

10:05 - 10:35

Q&A    

10:35 - 10:45

Quantitative and Qualitative Aspects of PROTAC Metabolism: Do they differ from small molecule?

Beth Williamson

 AstraZeneca, UK

10:45 -11:15

Q&A

 

 

11:15 - 11:25

Vendor Presentation -999Elite™ Cryopreserved Human Hepatocytes

Albert Li

11:25 - 11:50

Q&A    

11:50- 11:55

Lunch Break    

11:55 - 12:55

SESSION IV: Drug Accumulation/Transporters

Session Introduction

Mitesh Patel  Novartis 

12:55 - 1:00

The Impact of Ion Trapping on the Cellular Accumulation of Highly Permeable Low Molecular Weight Acidic Drugs

Dallas Bednarczyk

Novartis

1:00 - 1:30

Q&A    

1:30 - 1:40

Validation of PXB Chimeric Mice with Humanized Liver to Predict Human Liver-to-Plasma Kpuu of OATP1B1 Substrates Bo Feng Vertex

1:40 - 2:10

Q&A    

2:10 - 2:20

Drug Interaction Mediated by Transporter Induction: Current Status and Perspective Xinning Yang FDA 2:20 - 2:50
Q&A     2:50 - 3:00
Vendor Presentation:   

3:00 - 3:10

Q&A    

3:10 - 3:15

SESSION V: COVID and ADME

Session Introduction

   

3:15 - 3:20

Plenary Lecture

High Throughput Screening and Real-World Biomarkers to Predict Drug-Drug Interactions for Drugs in Clinical Trials for COVID19

Kathy Giacomini  UCSF

3:20 - 4:00 

Plenary Lecture

ADME data on Remdesivir/Treatment Efficacy

Yurong Lai Gilead

4:00 - 4:40

Q&A

   

4:40 - 4:50 

Closing Remarks      4:50 - 4:55

Workshops

Session I: ADME Prediction Tools for Old and New Therapeutic Modalities

Session II: Transporter-Mediated Drug Disposition

Session III: Bioanalysis of New Therapeutic Modalities

Sessin IV: New Clearance Prediction Models

 

Registration

Click here to register for the HT-ADME conference online.

HT-ADME 2021 will take place June 22-23, 2021

Virtual Event

 

The Boston Society

The Boston Society (R) is an internationally-recognized NON-PROFIT organization dedicated to bringing the best scientific ideas to industrial practice through focused, timely workshops and conferences. 501(c)3

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