*Speakers and titles are subject to change. Updated 6/20/18

June 21, 2018

Session

 

Speaker

Company

Time

Registration and Breakfast

7:30 - 8:30

Conference Opening

Stephen Johnston

Broad Institute

8:30 - 8:40

SESSION I: Developing Strategies in the ADME Discipline

Session Chairs: Stephen Johnston, the Broad Institute and Steven Louie, BioIVT

Session Introduction   

   

8:40 - 8:45

“ADME SAR: The Origination, Current State and Future Possibilities, Shaped by Strategy, Science and Technology”

 Matthew Troutman

Pfizer

8:45 - 9:15

“Incorporating Human Dose Projection in Early Lead Optimization - Good or Bad Idea?”

Sean Kim 

Blueprint Medicines

9:15 - 9:45

"Adapting and Readapting in the  Outsourcing Era"

 Sujal Deshmukh

Novartis 

9:45 - 10:15

Break    

10:15 - 10:35

SESSION II: New Technologies and Approaches in ADME Science

Session Chairs: Ian Knemeyer, Merck and John Janiszewski, Sound Analytics

 

Session Introduction

 

 

10:35 - 10:40

"Acoustic-OPP-MS: The Next Generation BioAnalytical Platform for Drug Discovery with Ultra-High Throughput"

Hui Zhang

Pfizer

10:40 - 11:10

"Leveraging in silico ADMET Models and Influence to Increase the Probability of Success in Discovery"

Elizabeth Joshi

Merck

11:10 - 11:40
"High Content Metabolic Stability Assay for Drug Discovery"

Marina Slavsky

Sanofi Genzyme

11:40 - 12:10
Complimentary Lunch    

12:10 - 1:10

Vendor Presentation

"Novel Hepatocyte and Enterocyte Technologies for the Evaluation of Human Drug Metabolism, Drug-Drug Interactions, and Drug Toxicity"

 Albert P. Li

InVitro ADMET Laboratories

1:10 - 1:40

"Translational DMPK Applications of Tissue Chip Technologies" Murat Cirit

MIT

 1:40 - 2:10
"Mass Spectrometry Imaging: Revealing Tissue Secrets for Early Drug Efficacy and Risk Assessment"

Stefan Linehan

Blue Tail Regenerative Therapeutics   2:10 - 2:40

Plenary Lecture

"Pursuing the Holy Grail of Predicting and Verifying Tissue Drug Concentrations:  A Proteomics and PET Imaging Approach"

Jashvant (Jash) Unadkat

 University of Washington  2:40 - 3:20
Break   

 

3:20 - 3:40

SESSION III: Emerging ADME Science for New Modalities & Omics in ADME

Session Chairs: Maria Fitzgerald, Sanofi and Dallas Bednarczyk, Novartis

Session Introduction

3:40 - 3:45

"ADME Implications of Chimeric Protein Degrader Druggability"

 Adam Gilbert

 Pfizer

3:45 - 4:15

"Pharmacologic Target Validation Utilizing siRNA-Mediated Knock Down of Hepatic Genes”

 Kenneth Koeplinger

 Merck

4:15 - 4:45

"ADME Characterization of Antibody Drug Conjugates"

Nagendra (Nag) Chemuturi   Novartis

4:45 - 5:15

Closing Remarks    

5:15 - 5:20

Evening Reception Sponsored by The Boston Society

 

5:20 - 6:20

Workshops

Session I:  Developing Strategies in the ADME Discipline

Session II: New Technologies and Approaches in ADME Science

Session III: Emerging ADME Science for New Modalities

 

Registration

Click here to register for the HT-ADME conference online.

HT-ADME 2018 will take place June 21, 2018 at:

Amgen

Cambridge, MA

The Boston Society

The Boston Society (R) is an internationally-recognized NON-PROFIT organization dedicated to bringing the best scientific ideas to industrial practice through focused, timely workshops and conferences. 501(c)3

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