*Speakers and titles are subject to change. Updated 5/31/19

June 20, 2019






Registration and Breakfast

7:30 - 8:30

Conference Opening

Stephen Johnston

Broad Institute

8:30 - 8:40

SESSION I: New Modalities

Session Chairs: Dallas Bednarczyk, Novartis

Session Introduction   


8:40 - 8:45

"Innovative Small Molecule Drugs: How Novel Strategies for Biotherapeutics will Expand the Design of Future Small Molecule Therapies"

 Timothy Olah


8:45 - 9:15

“Degrader Drug Space: What Rules?”

 Chris Nasveschuk

 C4 Therapeutics

9:15 - 9:45

"General ADME Properties of the GalNAc-siRNA Conjugates"

Robin McDougall 


9:45 - 10:15


10:15 - 10:45

SESSION II: Computational ADME Approaches

Session Chairs: Steven Louie, BioIVT


Session Introduction



10:45 - 10:50

"In Silico ADME Modeling Approaches: Are We There Yet?"

Archana Simmons


10:50 - 11:20

"Evaluation Of Deep Learning Algorithms In In Silico ADME Modeling"

Hua Gao 


11:20 - 11:50
Complimentary Lunch    

11:50 - 1:20

Plenary Lecture

"Passive Distribution of Drugs to Intracellular Targets: Moving Towards an Understanding of the Passive Determinants of Cellular and Sub-Cellular Drug Distribution"

Dennis Scott


 1:20 - 2:00

SESSION III: New Technologies

Session Chairs: Wilson Shou, BMS

Session Introduction

2:00 - 2:05

“High-Throughput ESI-MS Enabled by the Acoustic Droplet Ejection to the Open-Port Probe Sampling Interface” 

 Chang Liu


2:05 - 2:35

"ADME-Omics: The Evolving Role of High-Throughput LC/MS in Drug Discovery"

John Janiszewski


2:35 -3:05




3:05 - 3:35

SESSION IV: Tissue Targeting

Session Chairs: Maria Fitzgerald, Sanofi

Session Introduction


3:35 - 3:40

"In Vitro and In Vivo Approaches and Applications of Tissue Kpuu"

Li Di   Pfizer

3:40- 4:10

"Medicinal Chemistry Design Principles for Liver Targeting Through OATP Transporters" Meihua Tu  Pfizer

4:10 - 4:40

Closing Remarks    

4:40- 4:45

Evening Reception Sponsored by The Boston Society


4:45- 6:00


Session I:  New Modalities

Session II: New Technologies and Approaches in ADME Science

Session III: Computational ADME Approaches

Sessin IV: Tissue Targeting



Click here to register for the HT-ADME conference online.

HT-ADME 2019 will take place June 20, 2019 at:


Cambridge, MA

The Boston Society

The Boston Society (R) is an internationally-recognized NON-PROFIT organization dedicated to bringing the best scientific ideas to industrial practice through focused, timely workshops and conferences. 501(c)3


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